[Modelling of ventricular tachycardia against a background of an elongated Q-T interval]

During the experiments on dogs we've created a mood of stable ventricular tachycardia induced by electrical stimulation of the left stellate ganglion at the elongated Q-T interval. The elongated cardiac systole--Q-T interval on ECG is induced by intravenous cesium chloride (l mmol/kg of dog's weight), which results in the disturbed myocardial electrolyte balance seen as tissue hypokalemia. In the dogs with electrical cardiac instability irritation of the left stellate ganglion resulted in polymorphic ventricular tachyarrhythmia in 83% of the animals. The created model has documented a role played by intracardiac pathology (electrolyte imbalance) in combination with the increased activity of the stellate ganglion in the mechanism of ventricular arrhythmia seen at the elongated Q-T interval.