Related Experiment Videos
Antibody-mediated marrow failure after allogeneic bone marrow transplantation
A J Barge1, G Johnson, R Witherspoon
1Fred Hutchinson Cancer Research Center, Seattle.
Blood
|October 1, 1989
Summary
Host antibodies, not just T cells, can cause marrow graft failure. Donor-specific antibodies can lead to complete graft failure or impaired marrow function, persisting for over 18 months post-transplant.
Area of Science:
- Immunology
- Transplantation Medicine
- Hematology
Background:
- Marrow graft failure is often linked to T cell-mediated rejection due to donor-recipient histocompatibility differences.
- The role of host antibodies in mediating graft failure has been less understood.