Related Experiment Video
Updated: Mar 11, 2026

Sealable Femtoliter Chamber Arrays for Cell-free Biology
Published on: March 11, 2015
Effects of cell cycle noise on excitable gene circuits
Alan Veliz-Cuba1, Chinmaya Gupta, Matthew R Bennett
1Department of Mathematics, University of Dayton, USA.
Abstract:
We assess the impact of cell cycle noise on gene circuit dynamics. For bistable genetic switches and excitable circuits, we find that transitions between metastable states most likely occur just after cell division and that this concentration effect intensifies in the presence of transcriptional delay. We explain this concentration effect with a three-states stochastic model. For genetic oscillators, we quantify the temporal correlations between daughter cells induced by cell division. Temporal correlations must be captured properly in order to accurately quantify noise sources within gene networks.
Related Concept Videos
Circadian Rhythms and Gene Regulation
Molecular Factors Affecting Cell Division
Several proteins function as internal regulators to ensure each cell cycle stage is completed faithfully before proceeding to the next. Regulator molecules may act directly or influence the activity or production of other...
Diversity in Cell Signaling Responses
Graded and Abrupt Responses
Some signaling systems generate...
Mitogens and the Cell Cycle
The Cell Cycle Control System
Cyclins and cyclin-dependent kinases (Cdks) are the primary cell cycle regulators and...
The Cell Cycle Control System

