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SANTAVAC ™: A Novel Universal Antigen Composition for Developing Cancer Vaccines

Petr G Lokhov1, Elena E Balashova

  • 1Institute of biomedical chemistry, P.O. Box: 119121, Pogodinskaya st., 10, Moscow. Russian Federation.

Recent Patents on Biotechnology
|December 2, 2016
PubMed
Abstract

Insights

SANTAVAC™ is a novel universal cancer vaccine targeting tumor vasculature. This anti-angiogenic vaccine shows high predicted efficacy in experimental models, potentially advancing cancer prevention and treatment strategies.

Area of Science:

  • Oncology
  • Immunology
  • Vaccinology

Background:

  • Universal cancer vaccines aim for broad cancer prevention.
  • Anti-angiogenic vaccines target tumor vasculature endothelial cells.
  • SANTAVAC™ is the first cancer vaccine utilizing endothelial cell heterogeneity.

Purpose of the Study:

  • To detail the development of SANTAVAC™.
  • To outline optimal production and composition for efficacy and safety.
  • To present a strategy for large-scale implementation and patent overview.

Main Methods:

  • Summarized SANTAVAC™ development data.
  • Described antigen composition for maximal efficacy and safety.
  • Outlined large-scale production and implementation strategy.

Main Results:

  • SANTAVAC™ demonstrated high predicted efficacy (up to 60-fold decrease in tumor-induced endothelial cells).
  • Immune targeting of tumor vasculature was achieved in experimental models.
  • Efficacy correlates with predicted tumor growth arrest.

Conclusions:

  • SANTAVAC™ is a promising universal antigenic composition.
  • It may accelerate the development of prophylactic and therapeutic cancer vaccines.
  • Potential applications include various solid cancer types.
Keywords:
CancerSANTAVACantigensendothelial cellsproteomic footprintinguniversalvaccine

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