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An Overview of Neolignans of the Genus Piper L.: Isolation Methods and Biological Activities
Arthur Ladeira Macedo1, Thais Carvalho Costa Dos Santos1, Alessandra Leda Valverde1
1Departamento de Quimica Organica, Instituto de Quimica, Universidade Federal Fluminense, Niteroi, Brazil.
Background:
The genus Piper L. has the shikimic acid pathway predominantly expressed, biosynthesizing many cinnamic acid derivatives (CAD).
Objective:
Neolignans comprise an important class of CAD that exhibit a wide range of pharmacological properties such as antibacterial, antitumor, insecticidal, anti-inflammatory, antioxidant, smooth muscle relaxant, neuroprotective, antiprotozoal and against platelet aggregation factor. These substances have been extracted and isolated from Piper species using different technics.
Results:
The present review aims to summarize extraction and isolation methods and biological activities of the different types of neolignans covering the period from 1968 to January 2016.
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