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Causative Agents of Aspergillosis Including Cryptic Aspergillus Species and A. fumigatus

Takahito Toyotome1

  • 1Obihiro University of Agriculture and Veterinary Medicine Diaghostic Center for Animal Health and Food Safety.

Medical Mycology Journal
|December 2, 2016
PubMed

Insights

Accurate identification of Aspergillus species, including cryptic ones, is crucial for treating aspergillosis. This review covers cryptic species, their exometabolome, and azole resistance in Aspergillus fumigatus.

Area of Science:

  • Medical Mycology
  • Infectious Diseases
  • Antimicrobial Resistance

Background:

  • Aspergillosis is a significant deep fungal infection caused by Aspergillus species.
  • Cryptic Aspergillus species present diagnostic challenges due to morphological similarities to known species.
  • Emerging azole resistance in Aspergillus fumigatus necessitates improved identification and susceptibility testing.

Purpose of the Study:

  • To review causative cryptic Aspergillus species and their exometabolome.
  • To discuss the phenomenon of azole resistance in Aspergillus fumigatus.
  • To highlight the importance of precise species identification and susceptibility evaluation.

Main Methods:

  • Literature review of cryptic Aspergillus species.
  • Description of the exometabolome of Aspergillus section Fumigati.
  • Discussion of azole resistance based on Japanese studies.

Main Results:

  • Cryptic Aspergillus species exhibit distinct susceptibility patterns and exometabolomes.
  • Azole-resistant Aspergillus fumigatus strains are increasingly reported in clinical and environmental settings.
  • Precise identification is essential for effective antifungal treatment.

Conclusions:

  • Accurate identification of all Aspergillus species, including cryptic ones, is vital for managing aspergillosis.
  • Understanding exometabolome variations and azole resistance mechanisms is critical for therapeutic strategies.
  • Further research is needed to address diagnostic and treatment challenges posed by Aspergillus species.

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