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MicroRNA-206 acts as a tumor suppressor in bladder cancer via targeting YRDC

Bisheng Huang1, Wei Zhai1, Guanghui Hu1

  • 1Department of Urology, Shanghai Tenth People's Hospital, Tongji University 301 Yanchang Road, Shanghai 200072, China.

American Journal of Translational Research
|December 2, 2016
PubMed

Insights

MicroRNA-206 (miR-206) is downregulated in bladder cancer, inhibiting tumor growth and spread by targeting YRDC. Restoring miR-206 shows therapeutic potential for bladder cancer by regulating YRDC.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • MicroRNAs (miRNAs) are key regulators in cancer development.
  • MicroRNA-206 (miR-206) is dysregulated in human bladder cancer, but its function is unclear.

Purpose of the Study:

  • Investigate the clinical significance of miR-206 in human bladder cancer.
  • Determine the effects of miR-206 and its target YRDC on bladder cancer phenotypes.

Main Methods:

  • Compared miR-206 expression in bladder cancer tissues/cell lines versus normal tissues/cells.
  • Overexpressed miR-206 and knocked down YRDC in bladder cancer cells.
  • Assessed effects on cell proliferation, colony formation, migration, invasion, and cell cycle.

Main Results:

  • miR-206 was significantly downregulated in bladder cancer.
  • miR-206 overexpression inhibited bladder cancer cell proliferation, migration, invasion, and induced G0/G1 cell cycle arrest.
  • Knockdown of YRDC mimicked miR-206 effects, and YRDC restoration partially reversed them.

Conclusions:

  • miR-206 acts as a tumor suppressor in human bladder cancer by targeting YRDC.
  • miR-206 may serve as a novel therapeutic target for bladder cancer treatment.
Keywords:
YRDCbladder cancermiR-206tumor suppressor

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