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Analysis of Congenital Heart Defects in Mouse Embryos Using Qualitative and Quantitative Histological Methods
Published on: March 10, 2020
Complete congenital heart block in a neonate with a complex congenital heart defect in Africa
Clovis Nkoke1, Edvine Yonta Wawo, Liliane Kuate Mfeukeu
1Faculty of Medicine and Biomedical Sciences, University of Yaoundé 1, Yaoundé, Cameroon.
Insights
Congenital heart block (CHB) is a rare disorder. This case highlights challenges in diagnosing and managing complex CHB in Sub-Saharan Africa, emphasizing antenatal screening.
Area of Science:
- Cardiology
- Pediatrics
- Neonatology
Background:
- Congenital heart block (CHB) is a rare condition, often with higher mortality when associated with structural congenital heart defects.
- Cases of CHB are infrequently reported in Sub-Saharan Africa (SSA).
Observation:
- A one-month-old neonate in Cameroon presented with bradycardia, mild cyanosis, and was diagnosed with complete CHB.
- Obstetrical ultrasound during pregnancy had noted fetal bradycardia.
- Clinical examination revealed bradycardia (62 bpm), mild cyanosis (SpO2 93%), with no signs of heart failure.
Findings:
- Twelve-lead ECG showed complete atrioventricular conduction block, junctional escape rhythm (59/min), left axis deviation, and biventricular hypertrophy.
- Two-dimensional echocardiography revealed complex congenital heart disease: dextrocardia, complete atrioventricular canal with a single atrium, mild atrioventricular valve regurgitation, and malposition of great vessels.
Implications:
- This case underscores the diagnostic and management challenges of complex CHB in low-resource settings.
- Enhanced antenatal care, including serial echocardiograms, can aid in early diagnosis and perinatal management for improved outcomes.
- Highlights the clinical value of high-quality antenatal care and screening for congenital heart defects.
Abstract:
Congenital heart block (CHB) is rare disorder that has a higher mortality when associated with structural congenital heart defects. Very few cases have been reported in Sub-Saharan Africa (SSA). We present a case of complete CHB associated with a complex congenital heart defect in a neonate in Cameroon. A 1-month-old neonate in Cameroon was referred for the evaluation of bradycardia. The obstetrical ultrasound done during pregnancy revealed fetal bradycardia without further evaluation. Clinical examination showed well a developed neonate with bradycardia at 62 beats/minute, and mild cyanosis with oxygen saturation at 93% at room air. There were no signs of heart failure. Twelve lead electrocardiogram (ECG) demonstrated a complete atrioventricular conduction block with a junctional escape rhythm at 59/minute, left axis deviation and bi-ventricular hypertrophy. Two-dimensional echocardiography revealed a complex congenital heart disease with the following abnormalities: dextrocardia, complete atrioventricular canal with a single atrium and mild atrioventricular valve regurgitation and malposition of the great vessels with a posterior aorta and an anterior pulmonary artery. This case report highlights the challenges in the diagnosis and management of complex CHBs in low resource settings. A properly performed pregnancy follow-up with serial echocardiograms could aid in antenatal diagnosis and plan perinatal management when appropriate in order to optimize outcome. This emphasizes the clinical value of high quality antenatal care and proper screening.
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