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Medullary thyroid carcinoma: a 30-year experience at one institution in Korea
Cho Rok Lee1, Sohee Lee2, Haiyoung Son3
1Department of Surgery, Yonsei University College of Medicine, Seoul, Korea.
Purpose:
The objective of this study was to review the clinical outcome and prognosis of patients with sporadic and hereditary medullary thyroid cancer (MTC) who were treated at a single tertiary hospital in Korea.
Methods:
We retrospectively reviewed the case files of 85 patients treated from August 1982 to February 2012.
Results:
In all, 65 patients (76.5%) had sporadic MTC and 20 patients (23.5%) had hereditary MTC. Patients in the sporadic group were older than in the hereditary group (P < 0.001). However, the hereditary group had more tumor multiplicity (P < 0.001) and bilaterality (P < 0.001). Neither survival rate was significantly different between the sporadic and hereditary groups (P = 0.775 and P = 0.866). By multivariate analysis, distant metastasis was a significant prognostic factor for overall and progression-free survival.
Conclusion:
In general, patients with MTC have favorable outcomes. Distant metastasis appears to be the strongest predictor of overall and progression-free survival.
