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[Sarcoidosis and uveitis : An update].

J G Garweg1,2,3

  • 1Swiss Eye Institute, Rotkreuz, Schweiz. justus.garweg@augenklinik-bern.ch.

Der Ophthalmologe : Zeitschrift Der Deutschen Ophthalmologischen Gesellschaft
|December 2, 2016
PubMed
Summary
This summary is machine-generated.

Ocular sarcoidosis often precedes systemic diagnosis, necessitating early detection for effective treatment. Advanced diagnostics and considering sarcoidosis in uveitis cases are crucial for preventing vision loss.

Keywords:
Angiotensin-converting enzymeDiagnosticsIntermediate uveitisTherapyUveitis

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Area of Science:

  • Ophthalmology
  • Rheumatology
  • Pulmonology

Background:

  • Ocular involvement occurs in up to one-third of sarcoidosis patients, often before systemic diagnosis.
  • Early diagnosis of ocular sarcoidosis is critical for therapeutic management and preventing vision loss.

Purpose of the Study:

  • To highlight the importance of early diagnosis of ocular sarcoidosis.
  • To discuss diagnostic strategies and therapeutic implications for ocular sarcoidosis.

Main Methods:

  • Review of clinical manifestations and diagnostic approaches for ocular sarcoidosis.
  • Discussion of biomarkers and imaging techniques for disease assessment.
  • Analysis of treatment strategies for different forms of ocular sarcoidosis.

Main Results:

  • Ocular sarcoidosis can manifest before systemic symptoms, making early diagnosis challenging.
  • Invasive procedures like bronchoalveolar lavage and biopsy may be needed if characteristic signs are absent.
  • Biomarkers like ACE and lysozyme are supportive but not specific; imaging and clinical signs are key.
  • Anterior uveitis often responds to topical steroids, while intermediate, posterior, and panuveitis require systemic therapy.
  • Immunomodulatory agents and biologics are increasingly used for refractory cases to prevent vision loss.

Conclusions:

  • Sarcoidosis should be considered in patients with uveitis, especially with characteristic findings, even without known systemic disease.
  • Prompt diagnosis and appropriate treatment, including systemic therapy and biologics for severe cases, are essential to preserve vision.
  • Integrated diagnostic and therapeutic approaches are vital for managing ocular sarcoidosis effectively.