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The potential impact of primary headache disorders on stroke risk

Chia-Lin Tsai1,2, Chung-Hsing Chou1,2, Pei-Jung Lee3

  • 1Department of Neurology, Tri-Service General Hospital, National Defense Medical Center, No.325, Sec. 2, Cheng-Kung Road, 11490, Taipei, Taiwan, Republic of China.

The Journal of Headache and Pain
|December 2, 2016
PubMed

Insights

Primary headache disorders (PHDs) increase the risk of ischemic stroke, particularly in females and individuals aged 45-64. This risk is time-dependent, becoming more apparent over two years post-diagnosis.

Area of Science:

  • Neurology
  • Epidemiology
  • Public Health

Background:

  • Primary headache disorders (PHDs) like migraine are common.
  • Limited research exists on PHDs as a stroke risk factor.
  • This study investigates the link between PHDs and stroke development.

Purpose of the Study:

  • To determine if patients with primary headache disorders have an increased risk of stroke.
  • To explore the association between PHDs and ischemic stroke incidence.

Main Methods:

  • A population-based cohort study comparing 1346 PHD patients with 5384 matched controls.
  • Utilized International Classification of Diseases codes for diagnosis.
  • Employed Cox proportional-hazards regressions to calculate hazard ratios (HR).

Main Results:

  • PHD patients showed a 1.49 times higher risk of ischemic stroke.
  • Migraine (HR=1.22) and tension-type headache (HR=2.29) were linked to increased ischemic stroke risk.
  • Increased risk observed in females, individuals aged 45-64, and over time post-diagnosis.

Conclusions:

  • Primary headache disorders are associated with a heightened risk of ischemic stroke.
  • This risk exhibits gender, age, and time-dependent characteristics.
  • PHDs warrant consideration in stroke risk assessment.
Abstract

Keywords:
Ischaemic strokeMigraineNon-migrainous headacheRisk factorTension-type headache

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