Association between the p53 codon 72 polymorphism and primary open-angle glaucoma risk: Meta-analysis based on 11...

Area of Science:

• Genetics
• Ophthalmology
• Molecular Biology

Background:

• The TP53 gene plays a crucial role in cellular functions like DNA repair and apoptosis.
• Previous studies on the association between TP53 codon 72 polymorphism and primary open-angle glaucoma (POAG) risk have produced inconsistent findings.
• Understanding genetic predispositions for POAG is vital for early detection and management.

Purpose of the Study:

• To conduct a meta-analysis to clarify the association between TP53 codon 72 polymorphism and POAG risk.
• To investigate potential ethnic differences in this association.

Main Methods:

• A systematic literature search was performed on PubMed and Web of Science databases.
• Eleven studies comprising 2541 POAG cases and 1844 controls were included in the meta-analysis.
• Pooled odds ratios (OR) and 95% confidence intervals (CI) were calculated, with stratified analyses by ethnicity.

Main Results:

• No significant overall association was found between TP53 codon 72 polymorphism and POAG risk, except in the allele genetic model.
• Stratified analyses revealed a significant association in Asian and Caucasian populations.
• The dominant genetic model indicated an elevated POAG risk in both overall and ethnic subgroups.

Conclusions:

• TP53 codon 72 polymorphism may be a significant genetic factor influencing POAG susceptibility, particularly in certain ethnic groups.
• Further large-scale, ethnicity-stratified studies are recommended to solidify these findings.
• This research contributes to understanding the genetic basis of primary open-angle glaucoma.