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The correlation between children's status asthmatics and interstitial lung disease

X-M Han1, Y-Y Cheng, Y-F Gong

  • 1Department of Pediatrics, Laiyang Central Hospital, Yantai City, Shandong Province, China. xuemei_han1@163.co.

European Review for Medical and Pharmacological Sciences
|December 2, 2016
PubMed

Insights

Children

Area of Science:

  • Pediatric Pulmonology
  • Immunology

Background:

  • Status asthmaticus and interstitial lung disease (ILD) are distinct pediatric respiratory conditions.
  • Understanding the immunological overlap between these conditions is crucial for effective treatment.

Purpose of the Study:

  • To investigate the correlation between pediatric status asthmaticus and interstitial lung disease (ILD).
  • To analyze specific immune markers in children with both conditions.

Main Methods:

  • Compared four groups: children with asthma and ILD, pure asthma, pure ILD, and healthy controls.
  • Measured Th1/Th2 balance, high-sensitivity C-reactive protein (hs-CRP), thymic stromal lymphopoietin (TSLP), monocyte chemoattractant protein-1 (MCP-1), and anti-Jo-1 antibody levels.

Main Results:

  • Children with asthma and ILD showed significantly lower Th1/Th2 levels and higher Th2 levels compared to controls.
  • Elevated levels of hs-CRP, TSLP, MCP-1, and anti-Jo-1 antibody were observed in children with asthma and ILD.

Conclusions:

  • Abnormal expression of Th1/Th2, hs-CRP, TSLP, MCP-1, and anti-Jo-1 antibody may be linked to pediatric status asthmaticus and ILD.
  • These markers could serve as potential indicators for the co-occurrence of these conditions.
Abstract

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