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Updated: Mar 11, 2026

Visualization of the Axonal Projection Pattern of Embryonic Motor Neurons in Drosophila
Published on: June 16, 2017
Current drug design to target the Semaphorin/Neuropilin/Plexin complexes
Lionel A T Meyer1, Justine Fritz1, Marie Pierdant-Mancera1
1a INSERM U1109 - MN3T Lab, Fédération de Médecine Translationnelle, Labex Medalis, University of Strasbourg , France.
Abstract:
The Semaphorin/Neuropilin/Plexin (SNP) complexes control a wide range of biological processes. Consistently, activity deregulation of these complexes is associated with many diseases. The increasing knowledge on SNP had in turn validated these molecular complexes as novel therapeutic targets. Targeting SNP activities by small molecules, antibodies and peptides or by soluble semaphorins have been proposed as new therapeutic approach. This review is focusing on the latest demonstration of this potential and discusses some of the key questions that need to be addressed before translating SNP targeting into clinically relevant approaches.
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