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Visit-to-visit blood pressure variability is a risk factor for all-cause mortality and cardiovascular disease: a

Jianqi Wang1, Xubo Shi, Changsheng Ma

  • 1The Cardiovascular Center of Beijing Tongren Hospital, Capital Medical University, Beijing, PR China.

Journal of Hypertension
|December 2, 2016
PubMed

Insights

Visit-to-visit variability (VVV) in systolic blood pressure (BP) is linked to increased risks of cardiovascular disease (CVD) and mortality. Standardized monitoring of BP VVV is recommended for high-risk patients to improve prognosis.

Area of Science:

  • Cardiology
  • Public Health
  • Epidemiology

Background:

  • Clinical studies suggest a link between visit-to-visit variability (VVV) of blood pressure (BP) and adverse cardiovascular outcomes.
  • Inconsistencies across studies necessitate a comprehensive analysis to clarify this association.

Purpose of the Study:

  • To conduct a systematic review and meta-analysis to determine the association between BP VVV and cardiovascular disease (CVD) and all-cause mortality.

Main Methods:

  • Searched PubMed and EMBASE databases up to May 18, 2014, for studies on BP VVV, CVD, and mortality.
  • Included 23 publications in the meta-analysis, utilizing a random effects model for data synthesis.

Main Results:

  • Elevated systolic BP VVV showed significant associations with increased all-cause mortality (RR 1.14, 95% CI: 1.09-1.18).
  • Systolic BP VVV was also linked to higher incidence of CVD (RR 1.12, 95% CI: 1.05-1.09), CVD mortality (RR 1.18, 95% CI: 1.09-1.28), coronary heart disease (CHD) incidence (RR 1.12, 95% CI: 1.06-1.19), and stroke incidence (RR 1.34, 95% CI: 1.11-1.61).

Conclusions:

  • Modest associations exist between systolic BP VVV and major adverse cardiovascular outcomes across diverse populations.
  • Standardized monitoring of BP VVV is crucial for high-risk individuals (e.g., those with diabetes, CKD, or history of stroke) in future clinical studies to better predict patient prognosis.
Abstract

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