Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Chronic lymphocytic leukemia with hypothalamic invasion.

M Garofalo¹, R Murali, I Halperin

¹Department of Neurology, St. Vincent's Hospital and Medical Center of New York, New York 10011.

|October 15, 1989

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Corrigendum: Elective and Emergency Deep Brain Stimulation in Refractory Pediatric Monogenetic Movement Disorders Presenting with Dystonia: Current Practice illustrated by Two Cases.

Neuropediatrics·2025

Same author

Roles of cytochromes P450 and ribosome inhibition in the interaction between two preoccupying mycotoxins, aflatoxin B1 and deoxynivalenol.

The Science of the total environment·2024

Same author

Editorial Expression of Concern: MicroRNA signatures of TRAIL resistance in human non-small cell lung cancer.

Oncogene·2024

Same author

Preliminary insights into RNA in CSF of pediatric SMA patients after 6 months of nusinersen.

Biology direct·2023

Same author

The pathogenetic basis for a disease continuum in early- and late-onset ataxia-dystonia supports a unified genetic diagnostic approach.

European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society·2023

Same author

Elective and Emergency Deep Brain Stimulation in Refractory Pediatric Monogenetic Movement Disorders Presenting with Dystonia: Current Practice Illustrated by Two Cases.

Neuropediatrics·2022

A rare central nervous system complication occurred in a patient with chronic lymphocytic leukemia (CLL). Leukemic cells infiltrated the brain, causing a hypothalamic lesion and confusion, a manifestation not previously documented in CLL.

Area of Science:

Neurology
Hematology
Oncology

Background:

Chronic lymphocytic leukemia (CLL) is a hematologic malignancy characterized by the proliferation of mature B-lymphocytes.
Central nervous system (CNS) involvement is uncommon in CLL compared to other leukemia types.
This case highlights a rare presentation of CNS complication in a patient with CLL.

Observation:

A patient with known CLL presented with new-onset headaches and confusion.
A computed tomography (CT) scan revealed a hyperdense lesion in the hypothalamus, causing obstruction of the foramina of Monro.
Leptomeningeal involvement was suspected due to the location and obstructive nature of the lesion.

Findings:

Cerebrospinal fluid (CSF) analysis during surgical decompression identified leukemic cells.

Related Experiment Videos

These cells exhibited monoclonal lambda B-cell markers, consistent with the patient's CLL.

Peripheral blood analysis confirmed the presence of similar leukemic cells.

Implications:

This case expands the known spectrum of CNS complications in chronic lymphocytic leukemia.
It underscores the importance of considering CNS involvement in CLL patients presenting with neurological symptoms.
Further research may be warranted to understand the mechanisms and frequency of CNS infiltration in CLL.