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Menopause Is Associated with Accelerated Lung Function Decline.

Kai Triebner1,2, Bobette Matulonga3, Ane Johannessen1,4

  • 11 Department of Clinical Science.

American Journal of Respiratory and Critical Care Medicine
|December 2, 2016
PubMed
Summary
This summary is machine-generated.

Menopause accelerates lung function decline, particularly forced vital capacity (FVC) and forced expiratory volume in one second (FEV1). This indicates a significant impact of reproductive aging on respiratory health in women.

Keywords:
latent class analysislung function declinemenopausereproductive agingsex hormones

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Area of Science:

  • Reproductive endocrinology and pulmonology.
  • Longitudinal cohort studies in respiratory health.

Background:

  • Menopause is linked to hormonal shifts affecting immunity, bone health, and potentially lung function.
  • The impact of menopause on lung function decline has not been extensively studied.

Purpose of the Study:

  • To investigate if menopause accelerates lung function decline, measured by FVC and FEV1.
  • To analyze the association between menopausal status and the rate of lung function deterioration.

Main Methods:

  • Utilized data from the European Community Respiratory Health Survey (n=1,438) including spirometry and reproductive health questionnaires.
  • Determined menopausal status using latent class analysis of hormone levels (FSH, LH) and menstrual patterns.
  • Employed linear mixed effects models to assess lung function decline, adjusting for covariates and including study center as a random effect.

Main Results:

  • Menopausal status was significantly associated with accelerated lung function decline.
  • Post-menopausal women showed an increased adjusted mean FVC decline of -12.5 ml/yr and FEV1 decline of -5.2 ml/yr.
  • Transitional menopausal women also exhibited accelerated decline, with FVC at -10.2 ml/yr and FEV1 at -3.8 ml/yr.

Conclusions:

  • Lung function, especially FVC, declines more rapidly in transitional and post-menopausal women than expected for age.
  • Clinicians should recognize that respiratory health may worsen during the reproductive aging process.
  • This study highlights the importance of considering menopausal status in the assessment of women's respiratory health.