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Parasitic Infections in Children with Chronic Spontaneous Urticaria

Ebru Arik Yilmaz1, Betul Karaatmaca, Cansin Sackesen

  • 1Department of Pediatric Allergy, Hacettepe University School of Medicine, Ankara, Turkey.

International Archives of Allergy and Immunology
|December 2, 2016
PubMed

Insights

Parasitic infections may cause chronic spontaneous urticaria (CSU) in children, even in non-tropical regions. Treating these infections can lead to CSU remission, especially when abdominal pain is present.

Area of Science:

  • Pediatric Allergy and Immunology
  • Infectious Diseases
  • Dermatology

Background:

  • Chronic spontaneous urticaria (CSU) in children is sometimes linked to parasitic infections, but a definitive causal relationship remains unclear.
  • This study investigated the prevalence of parasitic infection-related CSU (PIRCSU) in pediatric patients.

Purpose of the Study:

  • To determine the prevalence of PIRCSU in children.
  • To identify factors associated with PIRCSU.

Main Methods:

  • Analysis of data from 211 children diagnosed with CSU.
  • Inclusion of stool examination results, antiparasitic medication use, and treatment response.
  • Definition of remission as urticaria disappearance for over 6 months, and PIRCSU as remission post-antiparasitic treatment.

Main Results:

  • Parasites were detected in 10% of patients, with Blastocystis hominis being the most common.
  • 10 patients (4.7%) met the criteria for PIRCSU after antiparasitic treatment.
  • PIRCSU patients exhibited higher erythrocyte sedimentation rates and more frequent gastrointestinal complaints, with abdominal pain being a significant risk factor (OR = 6.60).

Conclusions:

  • Parasitic infections can be a cause of CSU in children, even outside tropical areas.
  • Treatment of parasitic infections may be crucial for CSU remission.
  • The presence of abdominal pain in pediatric CSU patients warrants investigation for parasitic infections.
Abstract

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