[Extramedullary nodular plasmocytic lymphoma]

Area of Science:

• Oncology
• Pathology
• Immunology

Background:

• Plasmacytic lymphoma is a rare malignancy.
• Cervical lymph node involvement can indicate advanced disease.
• Granulomatous inflammation may precede lymphomagenesis.

Observation:

• A 71-year-old woman presented with cervical lymphadenopathy.
• The lymphoma subsequently spread to mediastinal nodes.
• The disease was fatal within two years.

Findings:

• Tumor cells lacked detectable monoclonal immunoglobulins in serum or cytoplasm.
• No rise in monoclonal serum immunoglobulins was observed.
• A four-year history of specific granulomatous inflammation of the skin and nodes preceded the lymphoma.

Implications:

• This case highlights a rare presentation of plasmacytic lymphoma.
• The absence of monoclonal immunoglobulins challenges typical diagnostic markers.
• Further research into the link between granulomatous inflammation and plasmacytic lymphoma is warranted.