Related Experiment Video
Updated: Mar 11, 2026
Software-Assisted Quantitative Measurement of Osteoarthritic Subchondral Bone Thickness
Published on: March 18, 2022
Bone Area Provides a Responsive Outcome Measure for Bone Changes in Short-term Knee Osteoarthritis Studies
Michael A Bowes1,2, Rose A Maciewicz3,4, John C Waterton3,4
1From the Imorphics; Biomedical Imaging Institute, Manchester Academic Health Sciences Centre, University of Manchester, Manchester; Respiratory, Inflammation, Autoimmunity Innovative Medicines and Early Development (IMED), AstraZeneca, Cambridge; Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds; UK National Institute for Health Research (NIHR) Leeds Musculoskeletal Biomedical Research Unit, Leeds, UK; Institute of Bone and Joint Research, Kolling Institute, University of Sydney, Sydney, Australia; Rheumatology Department, Royal North Shore Hospital, St. Leonards, Australia. mike@imorphics.com.
Objective:
To analyze the 3-D bone area from an osteoarthritis (OA) cohort demonstrating no change in cartilage thickness.
Methods:
Twenty-seven women with painful medial knee OA had magnetic resonance images at 0, 3, and 6 months. Images were analyzed using active appearance models.
Results:
At 3 and 6 months, the mean change in medial femoral bone area was 0.34% (95% CI 0.04-0.64) and 0.61% (95% CI 0.32-0.90), respectively. Forty-one percent of the subjects had progression greater than the smallest detectable difference at 6 months.
Conclusion:
In this small cohort at high risk of OA progression, bone area changed at 3 and 6 months when cartilage morphometric measures did not.
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