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Updated: Mar 11, 2026

Preparation and Evaluation of 99mTc-labeled Tridentate Chelates for Pre-targeting Using Bioorthogonal Chemistry
Published on: February 4, 2017
New precipitation method for isolation of 99mTc from irradiated 100Mo target
M Gumiela1, J Dudek1, A Bilewicz1
1Institute of Nuclear Chemistry and Technology, Dorodna 16, 03-195 Warsaw, Poland.
Abstract:
Technetium-99m is the most widely used radionuclide in nuclear medicine. This work describes the method to separate 99mTc from irradiated 100Mo target. For this purpose we utilized formation of ammonium molybdenum phosphate (AMP) and have optimized the four parameters of the process. The proposed process is promising and allows fast separation of macroamounts of molybdenum without co-precipitation of 99mTc. The concentration of molybdenum in solution after precipitation of AMP was lower than 300 µg ml-1. Additional purification using AnaLigTc-02 is required to obtain solution with lower concentration of molybdenum.

