[The effect of particle size on the pharmacokinetics of piroxicam]

Two preparations of Piroxicam cps. (10 mg) VUFB Prague, prepared from crystalline and micronized substance, were compared. The release of the active ingredient into the solution in the medium of artificial gastric juice in vitro was examined. The results show that Piroxicam prepared from micronized substance corresponds to the preparation Felden cps. On the other hand, the release of the active ingredient from the preparation prepared from crystalline substance is lower. The pharmacokinetic parameters of Piroxicam from micronized substance are practically consonant to similar parameters of the preparation Felden cps. In Piroxicam prepared from crystalline substance there was a decrease in the rapidity of absorption, which, however, was not statistically significant in the group of volunteers under study. Other pharmacokinetic parameters were practically the same as in the other preparations described.