[Technetium 99m Tc labeled lipoproteins. I. Preparation and evaluation of quality]

Technetium 99m Tc labelled lipoproteins are novel diagnostic agents suitable for the study of the lipoprotein metabolism and prospectively for picturing the specific receptors. The paper reports the first results of the preparation and quality evaluation of very low density lipoproteins (VLDL) labelled with technetium 99m Tc. This radionuclide is, due to its advantageous properties, preferentially employed in nuclear medicine. The present paper resulted in a successful attempt to bind technetium 99m Tc to a lipoprotein carrier with selective transport and targeted organ-specific biodistribution.