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Related Concept Videos

Cooperative Allosteric Transitions01:58

Cooperative Allosteric Transitions

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Cooperative allosteric transitions can occur in multimeric proteins, where each subunit of the protein has its own ligand-binding site. When a ligand binds to any of these subunits, it triggers a conformational change that affects the binding sites in the other subunits; this can change the affinity of the other sites for their respective ligands. The ability of the protein to change the shape of its binding site is attributed to the presence of a mix of flexible and stable segments in the...
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Allosteric Regulation01:08

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Allosteric regulation of enzymes occurs when the binding of an effector molecule to a site that is different from the active site causes a change in the enzymatic activity. This alternate site is called an allosteric site, and an enzyme can contain more than one of these sites. Allosteric regulation can either be positive or negative, resulting in an increase or decrease in enzyme activity. Most enzymes that display allosteric regulation are metabolic enzymes involved in the degradation or...
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Allosteric Proteins-ATCase01:19

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Binding sites linkages can regulate a protein's function.  For example, enzyme activity is often regulated through a feedback mechanism where the end product of the biochemical process serves as an inhibitor.
Aspartate transcarbamoylase (ATCase) is a cytosolic enzyme that catalyzes the condensation of L-aspartate and carbamoyl phosphate to  N-carbamoyl-L-aspartate. This reaction is the first step in pyrimidine biosynthesis. UTP and CTP, the end products of the pyrimidine synthesis...
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Ligand Binding and Linkage00:49

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Allosteric proteins have more than one ligand binding site; the binding of a ligand to any of these sites influences the binding of ligands to the other sites. When a protein is allosteric, its binding sites are called coupled or linked.  In the case of enzymes, the site that binds to the substrate is known as the active site and the other site is known as the regulatory site. When a ligand binds to the regulatory site, this leads to conformational changes in the protein that can influence...
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Related Experiment Video

Updated: Mar 11, 2026

Optimization of Synthetic Proteins: Identification of Interpositional Dependencies Indicating Structurally and/or Functionally Linked Residues
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Decoding the Polyphyletic Flexibility of Allosteric Modular Networks: Progress and Perspectives.

Yanan Yu1, Zhong Wang1, Yongyan Wang1

  • 1Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, China.

Critical Reviews in Eukaryotic Gene Expression
|December 3, 2016
PubMed
Summary
This summary is machine-generated.

This review explores dynamic modular network evolution, moving beyond static analysis. Understanding these transformations offers insights into disease treatment by examining adaptive balancing in biological systems.

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Area of Science:

  • Systems Biology
  • Network Science
  • Genomics

Background:

  • Current module detection methods primarily analyze static graphs.
  • Understanding genotypic networks and phenotypic robustness requires dynamic analysis.
  • Modular architecture plays a crucial role in biological system adaptability.

Purpose of the Study:

  • To reveal mechanisms of polyphyletic architectural transformation in modular networks.
  • To explore the role of modular boundary evolution and oscillating factors.
  • To provide insights into the dynamics of allosteric modular interactive networks.

Main Methods:

  • Review of current literature on modular network analysis.
  • Analysis of modular boundary evolutions and oscillating factors.
  • Discussion of flexible modular organization and adaptive balancing.

Main Results:

  • Flexible modular organization demonstrates adaptive balancing through allosteric regulation.
  • Novel biological alterations can be uncovered beyond engineering properties.
  • Multipotent functional changes in modular architecture are identified.

Conclusions:

  • Dynamic analysis of modular networks is essential for understanding biological adaptability.
  • Allosteric modular interactive networks offer potential applications in disease treatment.
  • Further research into modular architecture dynamics can advance therapeutic strategies.