Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Aneurysm II: Clinical Manifestations and Diagnostic Studies01:21

Aneurysm II: Clinical Manifestations and Diagnostic Studies

459
Thoracic, aortic arch and abdominal aneurysms are significant vascular conditions that can present with various clinical manifestations and lead to serious complications. Understanding these manifestations and the appropriate diagnostic studies is essential for effective management and treatment.Thoracic Aortic AneurysmsThoracic aortic aneurysms often remain asymptomatic until they reach a size that impinges on adjacent structures. They typically cause deep, diffuse chest pain that radiates to...
459
Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

681
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
681
Aneurysm I: Introduction01:30

Aneurysm I: Introduction

573
An aortic aneurysm is a localized outpouching or dilation at a weak point in the artery wall. It may involve different parts of the aorta, such as the abdominal aorta, aortic arch, or thoracic aorta.Etiological factorsSeveral disorders are associated with aortic aneurysms.Congenital causes, such as primary connective tissue disorders like Marfan syndrome, impact the integrity and strength of connective tissues, notably affecting the aorta. Marfan syndrome is a genetic disorder that specifically...
573
Aneurysm III: Interprofessional Care01:26

Aneurysm III: Interprofessional Care

425
Aneurysm management involves either conservative medical therapy or surgical intervention, depending on the size and symptoms of the aneurysm. Conservative management is generally reserved for smaller, asymptomatic aneurysms, while larger or symptomatic aneurysms often necessitate surgical repair.Conservative Medical TherapyFor small, asymptomatic aneurysms, particularly abdominal aortic aneurysms (AAA) less than 5.5 centimeters in diameter, conservative medical therapy is recommended. This...
425
Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

Blood Studies for Cardiovascular System I: Cardiac Biomarkers

1.0K
Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
1.0K
Aortic Regurgitation II: Clinical Features and Diagnostic Tests01:22

Aortic Regurgitation II: Clinical Features and Diagnostic Tests

731
Aortic valve regurgitation (AR) occurs when the aortic valve fails to close properly, allowing blood to flow backward from the aorta into the left ventricle. This backflow can result in two distinct clinical presentations: acute and chronic AR, each characterized by its own set of symptoms and physical findings.Acute Aortic RegurgitationAcute AR presents with a sudden onset of severe symptoms. Patients typically experience profound dyspnea (shortness of breath), chest pain, and signs of left...
731

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Response to critical reflections on the ESCAPER study.

Scandinavian cardiovascular journal : SCJ·2026
Same author

Targeted proteomics of extreme vascular phenotypes in type 1 diabetes: the ESCAPER study.

Cardiovascular diabetology·2026
Same author

A digital health program enhances walking capacity and health status in symptomatic peripheral artery disease.

European heart journal. Digital health·2026
Same author

Elderly escapers from cardiovascular complications and death despite high arterial stiffness: why are they protected?

Journal of hypertension·2026
Same author

Comparative safety of direct oral anticoagulants and low-molecular-weight heparin in patients with venous thromboembolism and cancer in Europe.

Journal of comparative effectiveness research·2026
Same author

Clinical characterization of individuals with obesity but normal blood pressure and heart function - a descriptive study from the SCAPIS cohort.

BMC cardiovascular disorders·2026

Related Experiment Video

Updated: Mar 11, 2026

Measurement of Pulse Propagation Velocity, Distensibility and Strain in an Abdominal Aortic Aneurysm Mouse Model
09:32

Measurement of Pulse Propagation Velocity, Distensibility and Strain in an Abdominal Aortic Aneurysm Mouse Model

Published on: February 23, 2020

6.9K

Inflammatory markers associated with abdominal aortic aneurysm.

Sarah Lindberg1, Moncef Zarrouk1, Jan Holst1

  • 1Lund University, Department of Vascular Diseases, Skåne University Hospital, S-205 02 Malmö, Sweden.

European Cytokine Network
|December 3, 2016
PubMed
Summary

Elevated inflammatory biomarkers like interleukin-6 (IL-6) and homocysteine are linked to abdominal aortic aneurysm (AAA) in 65-year-old men. These markers, along with smoking and antihypertensive use, predict AAA risk.

Keywords:
ET-1IL-6SuPARTNF-alphaabdominal aortic aneurysmbiomarkers

More Related Videos

Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty
10:03

Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty

Published on: January 28, 2020

5.9K
Ultrasound Imaging of the Thoracic and Abdominal Aorta in Mice to Determine Aneurysm Dimensions
06:08

Ultrasound Imaging of the Thoracic and Abdominal Aorta in Mice to Determine Aneurysm Dimensions

Published on: March 8, 2019

20.9K

Related Experiment Videos

Last Updated: Mar 11, 2026

Measurement of Pulse Propagation Velocity, Distensibility and Strain in an Abdominal Aortic Aneurysm Mouse Model
09:32

Measurement of Pulse Propagation Velocity, Distensibility and Strain in an Abdominal Aortic Aneurysm Mouse Model

Published on: February 23, 2020

6.9K
Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty
10:03

Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty

Published on: January 28, 2020

5.9K
Ultrasound Imaging of the Thoracic and Abdominal Aorta in Mice to Determine Aneurysm Dimensions
06:08

Ultrasound Imaging of the Thoracic and Abdominal Aorta in Mice to Determine Aneurysm Dimensions

Published on: March 8, 2019

20.9K

Area of Science:

  • Cardiovascular Medicine
  • Inflammation Research
  • Biomarker Discovery

Background:

  • Abdominal aortic aneurysm (AAA) is characterized by inflammation, extracellular matrix degradation, and vascular smooth muscle cell depletion.
  • Identifying reliable biomarkers for AAA is crucial for early detection and risk stratification.

Purpose of the Study:

  • To evaluate the relationship between AAA and inflammatory biomarkers: interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), endothelin-1 (ET-1), and soluble urokinase-type plasminogen activator receptor (suPAR).
  • To determine if these biomarkers can independently predict AAA in 65-year-old men during ultrasound screening.
  • To assess correlations between aortic diameter and blood levels of these biomarkers.

Main Methods:

  • Comparison of biomarker levels in 65-year-old men with and without AAA identified via ultrasound screening.
  • Logistic regression analysis to identify independent predictors of AAA.
  • Correlation analysis between aortic diameter and biomarker levels.

Main Results:

  • Significant differences in leukocyte count, homocysteine, TNF-α, IL-6, ET-1, suPAR, ankle-brachial index (ABI), creatinine, cholesterol levels, smoking habits, and antihypertensive/lipid-lowering drug use were observed between men with and without AAA.
  • Logistic regression identified IL-6, homocysteine, HDL cholesterol, ABI, smoking habits, and antihypertensive drug use as significant predictors.
  • Significant correlations between aortic diameter and TNF-α, IL-6, ET-1, and suPAR were found in the overall population and in men with AAA.

Conclusions:

  • Several inflammatory biomarkers are elevated and correlate with aortic diameter in 65-year-old men with AAA.
  • IL-6, homocysteine, and antihypertensive medication use are independent predictors of AAA, alongside established risk factors like smoking and atherosclerosis.