Myeloid-derived suppressor cells and their role in pancreatic cancer
1Department of Cell Biology, S. Arthur Localio Laboratory, New York University School of Medicine, New York, NY, USA.
Cancer Gene Therapy
|December 3, 2016
Abstract:
Pancreatic cancer is a devastating disease and ranks as the third most common cause of cancer-related death. Like many cancers, there has been increased interest in the role of the immune system in the progression and development of pancreatic cancer. In particular, immunosuppression within the tumor microenvironment (TME) is thought to impair the host's antitumor response. In this article, we review myeloid-derived suppressor cells and their contribution to this immunosuppression within the pancreatic TME.
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