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Renin-angiotensin-aldosterone system gene polymorphisms in gestational hypertension and preeclampsia: A case-control

Xun Li1, Hongzhuan Tan1, Shujin Zhou2

  • 1Xiangya School of Public Health, Central South University, 90 Xiangya Road, Changsha, Hunan, China.

Scientific Reports
|December 3, 2016
PubMed

Insights

Genetic variations in the renin-angiotensin-aldosterone system (RAAS) are linked to pregnancy-induced hypertension (PIH). Specific SNPs in AGT and AGTR1 genes show associations with gestational hypertension and preeclampsia in a Chinese population.

Area of Science:

  • Genetics
  • Obstetrics
  • Cardiovascular Medicine

Background:

  • Pregnancy-induced hypertension (PIH), encompassing preeclampsia (PE) and gestational hypertension (GH), shares risk factors with cardiovascular diseases (CVDs).
  • Single nucleotide polymorphisms (SNPs) in renin-angiotensin-aldosterone system (RAAS) genes are associated with CVDs, suggesting their potential role in PIH genetics.

Purpose of the Study:

  • To investigate the association between hypertension-related RAAS gene SNPs and PIH in a Chinese population.
  • To explore potential gene-age interactions influencing the genetic susceptibility to PIH.

Main Methods:

  • Recruited 130 PE cases, 67 GH cases, and 316 controls from a Chinese population.
  • Selected six candidate SNPs within RAAS genes for analysis.
  • Employed multiple logistic regression, adjusting for maternal age, fetal sex, and gestational diabetes mellitus, with stratified analyses by maternal age.

Main Results:

  • A significant association was found between the angiotensinogen (AGT) rs3789678 T/C SNP and GH (p=0.0088).
  • The angiotensin II receptor type 1 (AGTR1) rs275645 G/A SNP showed a significant association with PE (p=0.0082).
  • Preliminary stratified analyses suggested maternal age may modify the impact of certain SNPs on PIH risk.

Conclusions:

  • Specific RAAS SNPs, namely AGT rs3789678 and AGTR1 rs275645, are associated with GH and PE, respectively, in the Chinese population.
  • The influence of these genetic variations on PIH may be modulated by maternal age, warranting further investigation into gene-age interactions.

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