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[Immunologic indicators in the treatment of recurrent respiratory diseases using peroral bacterial vaccines]
Insights
Bacterial vaccines, including Broncho-vaxom, improved respiratory health in 80% of children with relapsing respiratory diseases. This study found these vaccines to be effective immunomodulating preparations with no observed side-effects.
Area of Science:
- Immunology
- Pediatrics
- Microbiology
Context:
- Recurrent respiratory tract infections pose a significant health burden in children.
- Bacterial vaccines are explored for their potential to modulate the immune system and prevent infections.
Purpose:
- To evaluate the efficacy and safety of bacterial vaccines (Broncho-vaxom and custom-prepared) in children with relapsing respiratory diseases.
- To assess the impact of these vaccines on specific immunological markers.
Summary:
- 95 children received Broncho-vaxom and 75 received a custom bacterial vaccine for relapsing respiratory diseases.
- Clinical improvement was observed in 80% of patients, with no reported side-effects.
- Significant reductions in IgM, IgA, salivary SIgA, and nitroblue tetrazolium test values were noted post-treatment.
Impact:
- Bacterial vaccines demonstrate utility as immunomodulating agents in pediatric respiratory infections.
- The findings support the use of bacterial vaccines for managing recurrent respiratory conditions in children.
- Further research into the specific mechanisms of immunomodulation by bacterial vaccines is warranted.
Abstract:
The authors treated on account of relapsing respiratory diseases 95 children with Broncho-vaxom (Lab. ltd. Meyrin, Geneva) and 75 children with bacterial vaccine prepared with regard to the microbiological examination. Restoration or improvement of the clinical condition was achieved in 80% of the patients. No side-effects were observed during treatment. As to investigated immunological indicators they recorded after treatment a significant reduction of IgM (P less than 0.001), IgA (P less than 0.01), SIgA in saliva (P less than 0.01), values of the nitroblue tetrazolium test (P less than 0.01) and (P less than 0.05). The assembled data revealed that bacterial vaccines are useful as immunomodulating preparations.