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Vitamins, derived from the Latin word for life, are essential organic substances required in small quantities for optimal growth and overall well-being. Unlike other organic nutrients, vitamins don't act as sources of energy or building materials but rather facilitate these nutrients' utilization by the body. Vitamins are predominantly coenzymes, assisting enzymes in specific chemical actions, like the oxidation of glucose for energy involving B vitamins. Most vitamins are not produced...
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Articles linked to this work by shared authors, journal, and citation graph.

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Short-term regulation of the renal vitamin D receptor in rats by 1,25-dihydroxycholecalciferol is calcium insensitive.

The Journal of nutrition·1992
Same author

Baculovirus-mediated expression of retinoic acid receptor type gamma in cultured insect cells reveals a difference in specific DNA-binding behavior with the 1,25-dihydroxyvitamin D3 receptor.

Proceedings of the National Academy of Sciences of the United States of America·1992
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Up-regulation of the vitamin D receptor in response to 1,25-dihydroxyvitamin D3 results from ligand-induced stabilization.

The Journal of biological chemistry·1992
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New concepts of vitamin D functions.

Annals of the New York Academy of Sciences·1992
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Sequences in the human parathyroid hormone gene that bind the 1,25-dihydroxyvitamin D3 receptor and mediate transcriptional repression in response to 1,25-dihydroxyvitamin D3.

Proceedings of the National Academy of Sciences of the United States of America·1992
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A new, highly sensitive assay for 1,25-dihydroxyvitamin D not requiring high-performance liquid chromatography: application of monoclonal antibody against vitamin D receptor to radioreceptor assay.

Analytical biochemistry·1992
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Updated: Mar 11, 2026

A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data
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UVB radiation, vitamin D and multiple sclerosis.

H F DeLuca1, L Plum1

  • 1Department of Biochemistry, University of Wisconsin-Madison, Madison, WI, USA. deluca@biochem.wisc.edu.

Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology
|December 3, 2016
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This summary is machine-generated.

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Area of Science:

  • Neuroimmunology
  • Endocrinology
  • Photobiology

Background:

  • Multiple Sclerosis (MS) incidence shows an inverse relationship with sunlight exposure.
  • Vitamin D, influenced by sunlight, was hypothesized to suppress MS.
  • 1α,25 dihydroxy vitamin D suppressed the EAE model of MS but caused hypercalcemia.

Purpose of the Study:

  • To investigate the role of vitamin D and light exposure in Multiple Sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis (EAE).
  • To re-evaluate the hypothesis that vitamin D suppresses MS.
  • To identify mechanisms by which light exposure impacts EAE.

Main Methods:

  • Administration of 1α,25 dihydroxy vitamin D to mice with EAE under varying calcium diets.
  • Evaluation of EAE development in vitamin D receptor knockout mice.
  • Exposure of mice with EAE to a narrow band of light (300-315 nm).

Main Results:

  • Vitamin D deficiency prevented EAE, contradicting the initial hypothesis.
  • Vitamin D receptor knockout mice did not develop EAE.
  • A specific narrow band of light (300-315 nm) prevented EAE without altering vitamin D levels.

Conclusions:

  • Vitamin D does not appear to suppress EAE; vitamin D deficiency may be protective.
  • Light exposure, specifically a narrow band, shows potential for preventing EAE independently of vitamin D.
  • Further research is warranted to explore narrow-band light therapy for MS treatment.