Confocal microscopy and imaging profilometry: A new tool aimed to evaluate aesthetic procedures

Area of Science:

• Aesthetic Medicine
• Dermatology
• Biomaterials

Background:

• The cosmetic surgery market is substantial, with millions of procedures performed annually.
• Hyaluronic acid (HA) fillers are widely used for facial rejuvenation.
• Objective evaluation methods for aesthetic treatments are crucial.

Purpose of the Study:

• To assess the efficacy, durability, and safety of a non-animal origin cross-linked hyaluronic acid filler.
• To evaluate a novel imaging system utilizing confocal microscopy for objective assessment of skin microrelief.
• To analyze changes in nasolabial fold topography after treatment.

Main Methods:

• Retrospective, observational, multi-centric study.
• Treatment of nasolabial folds with cross-linked hyaluronic acid of varying molecular weights.
• Confocal microscopy and profilometric techniques to analyze 150 silicone casts from 25 patients.
• Comparison of skin roughness at baseline (T0), T1, and T2.

Main Results:

• Significant reduction in skin roughness of nasolabial folds observed.
• Right fold roughness decreased by 50% at T2 versus T0 and 40% versus T1.
• Left fold roughness decreased by 45% at T2 versus T0 and 35% versus T1.
• No adverse side effects were reported during the study period.

Conclusions:

• Cross-linked hyaluronic acid fillers demonstrate significant efficacy in improving nasolabial fold appearance.
• Confocal microscopy provides a precise and safe imaging system for objective evaluation of aesthetic treatment results.
• This novel imaging approach enhances the objective assessment of skin microrelief changes post-treatment.