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Updated: Aug 18, 2026

Evaluation of Respiratory System Mechanics in Mice using the Forced Oscillation Technique
Published on: May 15, 2013
[Changes in lung compliance and maximal expiratory flow-volume curves when breathing air and an He-O2 mixture in
Abstract:
Lung compliance (CL) and maximal expiratory flow-volume curves (MEFV) breathing air and helium-oxygen mixture in 34 healthy nonsmokers and 55 young light smokers were studied. The difference of FEV1%, PEFR and MMEF between smokers and nonsmokers were statistically significant. The results of small airway function tests were compared and analysed. In the 55 smokers, 38(69.1%) showed frequency dependence of dynamic compliance (FDC), only 5(9.1%) had an abnormal V25/HT and 4(7.3%) showed an abnormal MMEF. of 48 smokers (31.3%) had an abnormal volume of isoflow (VisoV), We concluded that among the small airway function tests FDC is the most sensitive one in light smokers.
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