[Research on the fundamental factors and conditions of gallstone formation]

The authors applied scanning electron microscope with synchronization of EDAX to detect the ultrastructure of gallbladder mucosa, metallic elements and their oxides, to observe the bacteria of the core of the gallstone; applied cholecystokinin to observe the effects of abnormal gallbladder contraction on stone formation; applied biochemical, immunological criteria to determine the association between liver and gallbladder diseases and gallstone; applied scanning electron microscope to compare the analysis of mechanical structure of gallstone. According to the results of research, the authors conclude: (1) The basic condition of the formation of the gallstone was the disturbance of physiological reaction of "integration" and "homeostasis" of liver-biliary system. (2) The essential factor of the formation of gallstone was the infection of liver-biliary system. (3) The formation of the gallstone structure was caused by changed physical and chemical mechanics of bile. (4) The synchronization treatment of liver-biliary was the principle of preventing and treating gallstone.