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Related Concept Videos

Skin Cancer01:30

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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
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Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
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The color of the skin is influenced by a number of pigments, including melanin, carotene, and hemoglobin. Recall that melanin is produced by cells called melanocytes, which are found scattered throughout the stratum basale of the epidermis. The melanin is transferred to the keratinocytes via melanosomes.
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Renewal of Skin Epidermal Stem Cells01:12

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The skin is divided into epidermis, dermis, and hypodermis, the skin's outermost, middle, and inner layers. The human epidermal layer regularly undergoes renewal, where old, dead cells are replaced by new cells. Epidermal stem cells or EpiSCs divide and differentiate to restore the lost cells. For the renewal process, some EpiSCs continuously self-renew. In contrast, few others differentiate into transit-amplifying cells, which later form prickle or spinous cells, followed by granular...
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Cancer arises from mutations in the critical genes that allow healthy cells to escape cell cycle regulation and acquire the ability to proliferate indefinitely. Though originating from a single mutation event in one of the originator cells, cancer progresses when the mutant cell lines continue to gain more and more mutations, and finally, become malignant. For example, chronic myelogenous leukemia (CML) develops initially as a non-lethal increase in white blood cells, which progressively...
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Combining Reflectance Confocal Microscopy with Optical Coherence Tomography for Noninvasive Diagnosis of Skin Cancers via Image Acquisition
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Extensive facial skin cancers.

T J Harris1

  • 1Senior surgeon, Department of Plastic and Reconstructive Surgery, Royal Brisbane Hospital, Brisbane, Queensland, Australia.

Journal of Wound Care
|December 3, 2016
PubMed
Summary
This summary is machine-generated.

This review covers extensive facial skin cancers, detailing their symptoms, progression, and current treatment options for better patient outcomes.

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Area of Science:

  • Dermatology
  • Oncology

Background:

  • Facial skin cancers represent a significant clinical challenge due to cosmetic and functional implications.
  • Early detection and appropriate management are crucial for effective treatment of these malignancies.

Purpose of the Study:

  • To provide a comprehensive overview of extensive skin cancers affecting the face.
  • To review the characteristic symptoms, natural disease progression, and available therapeutic modalities.

Main Methods:

  • Literature review of extensive skin cancers of the face.
  • Synthesis of information on clinical presentation, histopathology, and treatment efficacy.

Main Results:

  • Detailed description of common facial skin cancer types, including basal cell carcinoma, squamous cell carcinoma, and melanoma.
  • Discussion of advanced disease signs and the impact on surrounding facial structures.
  • Overview of established and emerging treatment strategies, such as surgery, radiation, and targeted therapies.

Conclusions:

  • Effective management of extensive facial skin cancers requires a multidisciplinary approach.
  • Understanding disease progression and treatment options is vital for optimizing patient care and prognosis.