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Updated: Mar 11, 2026

Characterizing RNA Modifications in Single Neurons Using Mass Spectrometry
Published on: April 21, 2022
Nucleotide modifications in messenger RNA and their role in development and disease
Veronica Dezi1, Chavdar Ivanov1, Irmgard U Haussmann2
1School of Biosciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, U.K.
Abstract:
Modified nucleotides in messenger RNA (mRNA) have been discovered over 40 years ago, but until recently little was known about which transcripts contain them and what their function is. High-throughput sequencing approaches revealed a dynamic landscape of the 'Epitranscriptome' for many mRNA modifications in various organisms from yeast to humans. Meanwhile, also many genes encoding mRNA-modifying enzymes and auxiliary proteins have been identified yielding functional insights by reverse genetics into their role in development and disease.
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