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Related Experiment Videos

Denitrogenation in pregnancy.

M C Norris1, M R Kirkland, M C Torjman

  • 1Department of Anesthesiology, Thomas Jefferson University, Philadelphia, PA 19107.

Canadian Journal of Anaesthesia = Journal Canadien D'Anesthesie
|September 1, 1989
PubMed
Summary
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Pregnancy significantly speeds up nitrogen washout, with parturients reaching 95% denitrogenation much faster than non-pregnant women. Both two minutes of breathing or four deep breaths of oxygen provide adequate protection against hypoxemia.

Area of Science:

  • Anesthesiology
  • Physiology

Background:

  • Pregnancy alters respiratory physiology, potentially affecting denitrogenation.
  • Efficient denitrogenation is crucial for preventing hypoxemia during anesthesia.

Purpose of the Study:

  • To compare the rate of nitrogen washout (denitrogenation) between pregnant and non-pregnant women.
  • To evaluate the effectiveness of different denitrogenation methods in parturients.

Main Methods:

  • Nitrogen concentration was monitored in ten pregnant and nine non-pregnant women.
  • Subjects breathed 100% oxygen for three minutes or took four deep breaths.
  • A circle anesthesia system with 8 L.min-1 fresh gas flow was used.

Main Results:

  • Parturients achieved 95% denitrogenation significantly faster (54.5 +/- 17.8 sec) than non-pregnant women (110.8 +/- 35.7 sec).

Related Experiment Videos

  • Three minutes of oxygen breathing reduced expired N2 to 1.0 +/- 0.2% in parturients.
  • Four deep breaths reduced expired N2 to 5.1 +/- 1.7% in parturients, offering limited additional protection.

    • Conclusions:

    • Pregnancy accelerates denitrogenation.
    • Both two minutes of tidal breathing and four deep breaths of 100% oxygen provide adequate denitrogenation.
    • These methods offer similar, clinically insignificant, protection against apnoeic hypoxemia in normal parturients.