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Related Experiment Videos

Ifosfamide cardiotoxicity in humans.

K Kandylis1, M Vassilomanolakis, S Tsoussis

  • 1Hellenic Anticancer Institute, St. Savas Hospital, Athens, Greece.

Cancer Chemotherapy and Pharmacology
|January 1, 1989
PubMed
Summary
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Ifosfamide (IFS) treatment can cause acute cardiac side effects like arrhythmias. Monitoring patients for cardiac abnormalities during IFS therapy is recommended due to potential risks.

Area of Science:

  • Oncology
  • Cardiology
  • Pharmacology

Background:

  • Ifosfamide (IFS) is an alkylating agent used in cancer treatment, related to cyclophosphamide.
  • While various side effects are known, cardiotoxicity in humans has not been previously established.

Purpose of the Study:

  • To report the occurrence of acute cardiac side effects associated with Ifosfamide (IFS) treatment.
  • To highlight the potential for supraventricular arrhythmias and ST-T wave changes as cardiac adverse events.

Main Methods:

  • Patients received Ifosfamide (IFS) doses ranging from 6.5 g/m2 to 10 g/m2, fractionated over 3 or 5 days.
  • IFS was administered intravenously over 4 hours daily, concurrently with 2-mercaptoethane sulphonate sodium (Mesna).

Main Results:

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  • Acute cardiac side effects, specifically supraventricular arrhythmias and ST-T wave changes, were observed during IFS treatment.
  • These cardiac arrhythmias were generally reversible upon drug discontinuation.
  • In one case, readministration of IFS resulted in a treatment-refractory arrhythmia.

Conclusions:

  • Ifosfamide (IFS) can induce acute cardiac side effects in patients.
  • Continuous cardiac monitoring is advised for patients undergoing IFS treatment.
  • Readministration of Ifosfamide may be contraindicated in patients who develop cardiac abnormalities.