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Related Concept Videos

Nuclear Stability03:18

Nuclear Stability

Protons and neutrons, collectively called nucleons, are packed together tightly in a nucleus. With a radius of about 10−15 meters, a nucleus is quite small compared to the radius of the entire atom, which is about 10−10 meters. Nuclei are extremely dense compared to bulk matter, averaging 1.8 × 1014 grams per cubic centimeter. If the earth’s density were equal to the average nuclear density, the earth’s radius would be only about 200 meters.
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Preparation and Reactivity of Gasless Nanostructured Energetic Materials
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Published on: April 2, 2015

Formin' a Nuclear Protection.

Jörg Renkawitz1, Michael Sixt1

  • 1Institute of Science and Technology Austria (IST Austria), am Campus 1, 3400 Klosterneuburg, Austria.

Cell
|December 3, 2016
PubMed
Summary
This summary is machine-generated.

The formin FMN2 protein creates a protective actin structure around the nucleus in migrating cells. This perinuclear actin cytoskeleton shields the cell nucleus and its DNA when cells squeeze through tight spaces.

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Area of Science:

  • Cell biology
  • Cytoskeleton dynamics
  • Nuclear mechanics

Background:

  • Cell migration is crucial for development and disease.
  • The nucleus must be protected during migration through confined environments.
  • Actin cytoskeleton dynamics play a key role in cell shape and movement.

Purpose of the Study:

  • To investigate the role of formin FMN2 in nuclear protection during cell migration.
  • To elucidate the mechanism by which the perinuclear actin cytoskeleton safeguards genomic content.

Main Methods:

  • Live-cell imaging of migrating cells.
  • Fluorescence microscopy to visualize actin and nuclear structures.
  • Genetic manipulation to study formin FMN2 function.

Main Results:

  • Formin FMN2 is essential for organizing a perinuclear actin cytoskeleton.
  • This actin structure directly surrounds and supports the nucleus.
  • Cells lacking functional FMN2 exhibit increased nuclear deformation and DNA damage during migration through constrictions.

Conclusions:

  • Formin FMN2 organizes a protective perinuclear actin cytoskeleton.
  • This structure is vital for maintaining nuclear integrity and genomic stability in migrating cells under physical stress.