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Tumor Interferon Signaling Regulates a Multigenic Resistance Program to Immune Checkpoint Blockade

Joseph L Benci1, Bihui Xu1, Yu Qiu1

  • 1Department of Radiation Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

Cell
|December 3, 2016
PubMed
Summary

Prolonged interferon signaling drives resistance to cancer immunotherapies like PD1 blockade. Inhibiting this signaling can restore anti-tumor immunity and improve responses to checkpoint inhibitors.

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