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Bone Remodeling

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.

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Related Experiment Video

Updated: Mar 11, 2026

Author Spotlight: Insights into the Use of Apple-Derived Cellulose Scaffolds for Bone Tissue Engineering

Author Spotlight: Insights into the Use of Apple-Derived Cellulose Scaffolds for Bone Tissue Engineering

Published on: February 23, 2024

Biomimetic Approaches for Bone Tissue Engineering.

Johnathan Ng¹, Kara Spiller², Jonathan Bernhard¹

¹1 Department of Biomedical Engineering, Columbia University , New York, New York.

Tissue Engineering. Part B, Reviews

|December 4, 2016

Summary

Tissue engineering offers a promising alternative to autologous bone grafts for bone defect repair. This approach utilizes scaffolds, cells, and bioreactors to create viable bone grafts, addressing limitations of current methods.

Keywords:

biomimetics bone tissue engineering

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Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect

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Published on: September 11, 2015

Area of Science:

Regenerative Medicine
Biomaterials Science
Orthopedic Surgery

Background:

Autologous bone grafts are the gold standard for bone defect treatment but have limitations.
Donor site morbidity and geometric constraints restrict the use of autologous bone grafts.
Tissue engineering presents a viable alternative to overcome these limitations.

Purpose of the Study:

To explore tissue engineering as a method for creating viable bone grafts.
To discuss strategies for enhancing bone graft survival and integration in vivo.
To review recent advancements and novel solutions for bone repair.

Main Methods:

Utilizing bone scaffolds and autologous cells within bioreactor culture systems.
Implementing vascularization strategies to ensure graft survival.
Investigating the role of inflammation in the bone repair process.

Main Results:

Tissue engineering can generate fully viable and biological bone grafts in vitro.
Vascularization strategies are crucial for promoting graft survival after implantation.
Understanding inflammation's role is key to optimizing bone repair.

Conclusions:

Tissue engineering offers a solution to the limitations of autologous bone grafts.
Combining scaffolds, cells, bioreactors, and vascularization strategies is a promising paradigm.
Inspiration from endochondral ossification provides new avenues for bone repair innovations.