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Updated: Mar 11, 2026

Loss- and Gain-of-function Approach to Investigate Early Cell Fate Determinants in Preimplantation Mouse Embryos
Published on: June 6, 2016
Neogenin regulates mitochondrial activity in pre-implantation mouse embryos
Kyoung Hee Choi1, Seon Hwa Hong2, Hye Ran Lee3
1CHA Fertility Center Seoul, Jung-gu, Seoul, 04637, Republic of Korea; Department of Animal Biotechnology, Bio-Organ Research Center/Animal Resources Research Center, Konkuk University, Seoul, 05029, Republic of Korea.
Abstract:
• Mitochondrial activation signaling pathways are not clearly identified. • Embryonic mitochondria activity is important for a successful pregnancy and live birth. • Neogenin is a multi-functional receptor that contributes to embryo development. • Neogenin as a receptor is related to mitochondrial activation and replication. • Neogenin could activate mitochondria in pre-implantation embryo development.
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