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Inherited thrombophilia: a double-edged sword
1Department of Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands.
Hematology. American Society of Hematology. Education Program
|December 4, 2016
Summary
Inherited thrombophilia, a clotting disorder, is frequently tested despite guidelines against it. Research explores its complex role in reproduction and potential benefits of anticoagulants for pregnancy complications.
Area of Science:
- Hematology
- Reproductive Medicine
Background:
- Inherited thrombophilia is a blood disorder increasing venous thromboembolism (VTE) risk.
- Testing practices have broadened beyond VTE to include arterial thrombosis and pregnancy complications.
- Not testing VTE patients for inherited thrombophilia is recommended by major societies ('Choosing Wisely').
Purpose of the Study:
- To discuss the evolving landscape of inherited thrombophilia testing.
- To highlight the 'double-edged sword' nature of inherited thrombophilia, particularly its reproductive associations.
- To review current research on anticoagulant therapy for pregnancy complications in women with inherited thrombophilia.
Main Methods:
- Review of current testing practices and clinical guidelines.
- Discussion of the dual role of inherited thrombophilia in male and female reproduction.
- Exploration of ongoing research into reproductive outcomes.
Main Results:
- Despite recommendations against it, inherited thrombophilia testing remains common.
- Inherited thrombophilia has a complex, two-sided association with reproductive health in both sexes.
- Research is investigating the efficacy of anticoagulants for improving pregnancy success in affected women.
Conclusions:
- The clinical utility of inherited thrombophilia testing is debated, yet it is widely performed.
- Further research is needed to understand the impact of inherited thrombophilia on embryo implantation and male fertility.
- Investigating anticoagulant therapy benefits for pregnancy complications in inherited thrombophilia is a key research area.
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