Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bone Marrow Sampling and Transplants01:22

Bone Marrow Sampling and Transplants

2.1K
Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
2.1K
Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

4.8K
Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
4.8K
Tissue Transplantation01:24

Tissue Transplantation

1.1K
Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
1.1K
Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

624
A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
624
Kidney Transplant II: Surgical Procedure01:26

Kidney Transplant II: Surgical Procedure

628
Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living...
628

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Late complications after atrial fibrillation ablation : Diagnosis and management].

Herzschrittmachertherapie & Elektrophysiologie·2026
Same author

Discovery of gene-alcohol interaction loci influencing blood pressure in 1.1 million individuals from multiple populations.

Research square·2026
Same author

The Association of Polygenic Risk Score With Glaucoma and Its Related Traits: Results From Two German Population-Based Studies.

Investigative ophthalmology & visual science·2026
Same author

Transitioning Between Treprostinil Formulations: Evidence and Strategies.

Advances in therapy·2025
Same author

Efficacy and safety of acalabrutinib with best supportive care versus best supportive care in patients with COVID-19 requiring hospitalization.

ImmunoHorizons·2025
Same author

A phase 1 study of durvalumab as monotherapy or combined with tremelimumab with or without azacitidine in patients with myelodysplastic syndrome.

Annals of hematology·2025

Related Experiment Video

Updated: Mar 11, 2026

Bone Marrow Transplantation Procedures in Mice to Study Clonal Hematopoiesis
08:00

Bone Marrow Transplantation Procedures in Mice to Study Clonal Hematopoiesis

Published on: May 26, 2021

14.4K

Nontransplant therapy for bone marrow failure.

Danielle M Townsley1, Thomas Winkler1

  • 1Hematology Branch, National Heart, Lung, and Blood Institute, Bethesda, MD.

Hematology. American Society of Hematology. Education Program
|December 4, 2016
PubMed
Summary

Nontransplant treatments for aplastic anemia are improving, with eltrombopag showing promise in refractory cases. Further research is needed, but these advances may reduce the need for stem cell transplants in the future.

More Related Videos

Bone Marrow Transplantation Platform to Investigate the Role of Dendritic Cells in Graft-versus-Host Disease
08:05

Bone Marrow Transplantation Platform to Investigate the Role of Dendritic Cells in Graft-versus-Host Disease

Published on: March 17, 2020

8.4K
Busulfan as a Myelosuppressive Agent for Generating Stable High-level Bone Marrow Chimerism in Mice
11:25

Busulfan as a Myelosuppressive Agent for Generating Stable High-level Bone Marrow Chimerism in Mice

Published on: April 1, 2015

14.2K

Related Experiment Videos

Last Updated: Mar 11, 2026

Bone Marrow Transplantation Procedures in Mice to Study Clonal Hematopoiesis
08:00

Bone Marrow Transplantation Procedures in Mice to Study Clonal Hematopoiesis

Published on: May 26, 2021

14.4K
Bone Marrow Transplantation Platform to Investigate the Role of Dendritic Cells in Graft-versus-Host Disease
08:05

Bone Marrow Transplantation Platform to Investigate the Role of Dendritic Cells in Graft-versus-Host Disease

Published on: March 17, 2020

8.4K
Busulfan as a Myelosuppressive Agent for Generating Stable High-level Bone Marrow Chimerism in Mice
11:25

Busulfan as a Myelosuppressive Agent for Generating Stable High-level Bone Marrow Chimerism in Mice

Published on: April 1, 2015

14.2K

Area of Science:

  • Hematology
  • Oncology
  • Immunology

Background:

  • Nontransplant therapies for acquired and constitutional aplastic anemia have advanced significantly in recent years.
  • Stem cell transplantation may become less frequently required for aplastic anemia patients in the future.

Purpose of the Study:

  • To review recent advancements in nontransplant therapeutic options for aplastic anemia.
  • To evaluate the potential of eltrombopag and danazol in treating aplastic anemia and related bone marrow failure syndromes.

Main Methods:

  • Review of recent clinical trials and therapeutic advancements in aplastic anemia.
  • Analysis of data on eltrombopag as a single agent and in combination with immunosuppressive therapy.
  • Evaluation of danazol's role in preventing telomere attrition in constitutional bone marrow failure.

Main Results:

  • Eltrombopag has demonstrated the ability to achieve trilineage hematologic responses in refractory aplastic anemia, reviving interest in growth factors.
  • Preliminary data suggest that adding eltrombopag to immunosuppressive therapy is promising.
  • Danazol has shown potential in preventing telomere attrition in constitutional bone marrow failure.

Conclusions:

  • Significant progress in nontransplant therapies may decrease the future need for stem cell transplants in aplastic anemia.
  • Eltrombopag shows promise, but long-term data on clonal evolution are necessary before its widespread adoption in treatment-naive patients.
  • Danazol offers a potential therapeutic benefit for constitutional bone marrow failure related to telomere disease.