Kinetics of isotype-specific humoral immunity in rubella vaccine-associated arthropathy

The present study documents the relationship between the development of rubella vaccine-associated arthropathy and isotype-specific rubella antibody responses in a prospectively studied population of 44 adult rubella hemagglutination inhibition (HAI) seronegative females undergoing rubella immunization. Rubella-specific IgM, IgG, and IgA antibody responses were evaluated prior to and at 1, 2, 3, 4, 5, 6, 12, and 24 weeks postvaccine. Detectable preimmunization rubella antibody of the IgG or IgA class was present using ELISA techniques in 6 of 6 individuals developing acute arthritis, 13 of 17 developing acute arthralgia, and in 15 of 21 with no joint manifestations postvaccine. Significantly elevated HAI IgM responses were noted 3 and 4 weeks postvaccine in the acute arthritis group but no significant differences were found in IgG and IgA rubella antibody levels postvaccine in relation to the presence or absence of joint manifestations at any time period postvaccine. The data support rubella reinfection as an important feature of rubella vaccine-associated arthropathy but do not support a role for quantitative differences in rubella IgG and IgA antibody in the pathogenesis of this syndrome.