Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bioavailability Study Design: Single Versus Multiple Dose Studies01:11

Bioavailability Study Design: Single Versus Multiple Dose Studies

305
Bioavailability studies are essential for understanding how a drug is absorbed, distributed, metabolized, and excreted in the body. These studies assess the extent and rate at which the active pharmaceutical agent becomes available at the site of action. The design of bioavailability studies can involve single-dose or multiple-dose regimens, each with distinct advantages and limitations.Single-dose studies are the preferred approach due to their simplicity and reduced drug exposure for...
305

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Transient Middle Cerebral Artery Occlusion in Rats as a Nonclinical Model of Ischemic Stroke: A Systematic Review.

Current issues in molecular biology·2026
Same author

Metabolic Reprogramming in Renal Cell Carcinoma: A Scoping Review with Quantitative Integration of Metabolomic Studies.

Journal of proteome research·2026
Same author

Transient focal neurological episodes in hereditary transthyretin-related amyloidosis treated with liver transplantation: electroencephalographic insights and clinical features.

Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis·2026
Same author

The Relationship Between Hippocampal Cerebrovascular Reactivity and Brain Structure in Older Age.

Human brain mapping·2026
Same author

Urinary metabolomics identifies lactate as a biomarker for bladder cancer detection and progression.

Molecular omics·2026
Same author

Performance of a gelling fibre and silicone foam dressing combination for wound management in the community: a sub-analysis of the VIPES study.

Journal of wound care·2026

Related Experiment Video

Updated: Mar 11, 2026

Positron Emission Tomography Imaging for In Vivo Measuring of Myelin Content in the Lysolecithin Rat Model of Multiple Sclerosis
08:40

Positron Emission Tomography Imaging for In Vivo Measuring of Myelin Content in the Lysolecithin Rat Model of Multiple Sclerosis

Published on: February 28, 2021

4.6K

Pediatric Multiple Sclerosis in Portugal: A Multicentre Study.

Ana Sofia Correia1, Luís Augusto2, Joana Meireles3

  • 1Neurology Department. Centro Hospitalar de Lisboa Ocidental. Lisboa. Portugal.

Acta Medica Portuguesa
|December 4, 2016
PubMed
Summary

This multicentric study in Portugal characterized pediatric multiple sclerosis (MS) in patients under 18. Findings reveal demographic, clinical, and treatment patterns similar to global data, highlighting the need for further research into pediatric MS.

More Related Videos

Assessing Primary Motor Cortex Excitability and Excitability Modulation by Pairing Transcranial Magnetic Stimulation with Electromyography
12:13

Assessing Primary Motor Cortex Excitability and Excitability Modulation by Pairing Transcranial Magnetic Stimulation with Electromyography

Published on: October 7, 2025

806
Protocol for Repetitive Transcranial Magnetic Stimulation with Symptom Provocation to Treat Obsessive-compulsive Disorder
11:17

Protocol for Repetitive Transcranial Magnetic Stimulation with Symptom Provocation to Treat Obsessive-compulsive Disorder

Published on: November 25, 2025

567

Related Experiment Videos

Last Updated: Mar 11, 2026

Positron Emission Tomography Imaging for In Vivo Measuring of Myelin Content in the Lysolecithin Rat Model of Multiple Sclerosis
08:40

Positron Emission Tomography Imaging for In Vivo Measuring of Myelin Content in the Lysolecithin Rat Model of Multiple Sclerosis

Published on: February 28, 2021

4.6K
Assessing Primary Motor Cortex Excitability and Excitability Modulation by Pairing Transcranial Magnetic Stimulation with Electromyography
12:13

Assessing Primary Motor Cortex Excitability and Excitability Modulation by Pairing Transcranial Magnetic Stimulation with Electromyography

Published on: October 7, 2025

806
Protocol for Repetitive Transcranial Magnetic Stimulation with Symptom Provocation to Treat Obsessive-compulsive Disorder
11:17

Protocol for Repetitive Transcranial Magnetic Stimulation with Symptom Provocation to Treat Obsessive-compulsive Disorder

Published on: November 25, 2025

567

Area of Science:

  • Neurology
  • Pediatrics
  • Immunology

Background:

  • Multiple sclerosis (MS) is typically diagnosed in young adults but can occur in pediatric populations.
  • Previous pediatric MS research in Portugal was limited to a single center.
  • Understanding pediatric MS is crucial due to its distinct presentation and long-term implications.

Purpose of the Study:

  • To evaluate the demographic, clinical, laboratorial, and neuroradiological characteristics of pediatric-onset MS in Portugal.
  • To compare childhood-onset MS with adolescent-onset MS.
  • To describe treatments used for pediatric MS.

Main Methods:

  • A retrospective, observational, multicentric study.
  • Inclusion criteria: patients diagnosed with MS before age 18.
  • Data collected included demographics, clinical presentation, laboratory findings, and neuroimaging.

Main Results:

  • 46 patients (72% female) were analyzed, with a mean age of 16.1 years at diagnosis.
  • Relapsing-remitting MS (98%) was most common; 74% had positive oligoclonal bands.
  • Childhood-onset cases showed more males and cerebrospinal fluid pleocytosis compared to adolescent-onset.

Conclusions:

  • This is the first multicentric study on pediatric MS in Portugal, providing valuable epidemiological data.
  • The characteristics align with international findings, suggesting a common disease profile.
  • Further research is needed to elucidate the specific mechanisms underlying pediatric MS.