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Enhanced nutrition improves growth and increases blood adiponectin concentrations in very low birth weight infants

Elin W Blakstad1,2,3, Sissel J Moltu4,5, Britt Nakstad1,2

  • 1Department of Pediatric and Adolescent Medicine, Akershus University Hospital, Lørenskog, Norway.

Food & Nutrition Research
|December 4, 2016
PubMed

Insights

Enhanced nutrition improved early growth in very low birth weight (VLBW) infants, potentially preventing later catch-up growth. Higher adiponectin levels in the intervention group correlated with better early weight gain and nutrient intake.

Area of Science:

  • Neonatal nutrition
  • Pediatric growth and development
  • Metabolic health in infancy

Background:

  • Optimal postnatal growth is crucial for very low birth weight (VLBW) infants.
  • Early growth trajectories may impact long-term metabolic syndrome risk.

Purpose of the Study:

  • To assess the impact of enhanced nutrient supply on growth and metabolic markers in VLBW infants.
  • To evaluate adiponectin, leptin, and insulin-like growth factor-1 (IGF-1) levels in response to nutritional intervention.

Main Methods:

  • Randomized controlled trial involving 50 VLBW infants.
  • Intervention group received enhanced nutrient supply; control group received standard supply.
  • Growth and metabolic markers measured up to 2 years corrected age.

Main Results:

  • Significant differences in weight and head growth between groups from birth to 2 years corrected age.
  • Enhanced nutrition improved early growth z-scores, while controls experienced a decline followed by catch-up.
  • Higher adiponectin levels observed in the intervention group at 5 months, correlating with weight gain and nutrient intake.

Conclusions:

  • Enhanced nutrient supply positively influenced early postnatal growth in VLBW infants.
  • Adiponectin levels at 5 months were associated with early nutrition and growth.
  • Early nutritional strategies may influence infant metabolic profiles.
Abstract

Keywords:
IGF-1adiponectinleptinmetabolic syndromepremature

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