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Related Experiment Video

Updated: Mar 11, 2026

Study Design for Navigated Repetitive Transcranial Magnetic Stimulation for Speech Cortical Mapping
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Cortical stimulation parameters for functional mapping.

Jacquelyn A Corley1, Pouya Nazari2, Vincent J Rossi3

  • 1Department of Neurosurgery, Duke University Hospital, DUMC Box 3807, Durham, NC 27710, United States.

Seizure
|December 4, 2016
PubMed
Summary

Cortical electrical stimulation responses vary widely between epilepsy patients. However, patient demographics and pathology did not predict these stimulation thresholds or afterdischarge levels in this study.

Keywords:
AfterdischargeCortex functional mappingPerirolandic epilepsySensory and motor cortexStimulation threshold

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Area of Science:

  • Neuroscience
  • Epilepsy Research
  • Neurosurgery

Background:

  • Cortical electrical stimulation is used to map brain function.
  • Patient responses to stimulation vary significantly.
  • Demographic and pathological factors are hypothesized to influence these responses.

Purpose of the Study:

  • To identify patient characteristics affecting cortical stimulation.
  • To quantify the variability in behavioral responses during epilepsy surgery.
  • To determine if factors like age, sex, or disease duration influence stimulation thresholds.

Main Methods:

  • Retrospective analysis of 92 epilepsy patient extra-operative cortical stimulation mapping records.
  • Evaluation of demographic data and stimulation thresholds for motor, sensory, and speech responses.
  • Assessment of seizure behavior induction and afterdischarge thresholds.

Main Results:

  • Analysis of 92 mapping reports revealed wide variability in stimulation thresholds between patients and within regions of the same patient.
  • Average minimum thresholds: motor 4.15mA, sensory 3.50mA, speech 4.48mA, afterdischarge 4.33mA.
  • No clinical or demographic factors were found to predict physiological response or afterdischarge threshold levels via multivariate analysis.

Conclusions:

  • Significant variability exists in cortical stimulation response thresholds.
  • No patient clinical or demographic factors predicted stimulation response or afterdischarge thresholds in this cohort.
  • Further research may be needed to understand the sources of response variability.