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Updated: Mar 11, 2026
08:07
Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma
Published on: April 12, 2019
7.7K
Osteoblastic Extraosseous Osteosarcoma of the Neck
Andro Košec1, Majda Vučić2, Vladimir Bedeković3
1Senior Resident, Department of Otorhinolaryngology and Head and Neck Surgery, University Hospital Center Sestre Milosrdnice, Zagreb, Croatia.
Summary
Extraosseous osteosarcoma of the neck is a rare and aggressive cancer. Advanced stages have a poor prognosis, often recurring locally despite treatment.
Area of Science:
- Oncology
- Surgical Pathology
- Head and Neck Surgery
Background:
- Extraosseous osteosarcoma (EOOS) is a rare malignancy distinct from primary bone osteosarcoma.
- Primary EOOS of the neck is exceedingly rare, with limited reported cases and undefined optimal therapy.
Observation:
- A case of an aggressive, advanced-stage, right-sided EOOS in a 48-year-old female is presented.
- The tumor presented as a large infra-parotid mass involving neck regions II and III.
- Initial treatment involved wide surgical resection followed by adjuvant chemoradiotherapy.
Findings:
- Histopathology confirmed an osteoblastic EOOS.
- The patient experienced rapid local recurrence with intraspinal propagation within 4 months post-surgery.
- Despite two surgical attempts and reirradiation, the disease progressed, leading to death 3 months later.
Implications:
- Advanced-stage EOOS of the neck demonstrates a high rate of local recurrence and poor prognosis.
- This case highlights the aggressive nature and challenges in managing neck EOOS.
- Further research is needed to establish effective therapeutic strategies for this rare tumor.
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