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Related Concept Videos

Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

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Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
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Drugs for Treatment of Ulcerative Colitis in IBD01:29

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Ulcerative colitis is a chronic inflammatory condition primarily affecting the colon and rectum. The primary drugs used in the treatment of ulcerative colitis are aminosalicylates. They exhibit anti-inflammatory and immunosuppressive properties. They modulate inflammatory mediators and inhibit the activity of nuclear factor κB (NF-κB). Aminosalicylates also reduce inflammation by inhibiting prostaglandin and leukotriene production and decreasing neutrophil chemotaxis and superoxide...
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Inflammatory Bowel Disease V: Surgical Management01:21

Inflammatory Bowel Disease V: Surgical Management

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Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
Here are some common surgical interventions for IBD:
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Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

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Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
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Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

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Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
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Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy01:30

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Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
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Analyzing Beneficial Effects of Nutritional Supplements on Intestinal Epithelial Barrier Functions During Experimental Colitis
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Ulcerative colitis.

Ryan Ungaro1, Saurabh Mehandru2, Patrick B Allen3

  • 1Division of Gastroenterology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Lancet (London, England)
|December 5, 2016
PubMed
Summary
This summary is machine-generated.

Ulcerative colitis is a chronic inflammatory colon disease with rising incidence. Management aims for remission using medications, but some patients may need surgery.

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Area of Science:

  • Gastroenterology and immunology.

Background:

  • Ulcerative colitis (UC) is a chronic inflammatory bowel disease affecting the colon.
  • Its global incidence is increasing, driven by genetic, immune, and environmental factors.
  • Pathology involves continuous mucosal inflammation from the rectum proximally.

Purpose of the Study:

  • To summarize the current understanding and management of ulcerative colitis.
  • To highlight the expanding therapeutic options for this condition.

Main Methods:

  • Review of existing literature on ulcerative colitis pathogenesis and treatment.
  • Clinical diagnosis confirmed by colonoscopy and histology.
  • Management strategies including medical therapy and surgical intervention.

Main Results:

  • Ulcerative colitis presents with bloody diarrhea and requires endoscopic and histological confirmation.
  • Treatment goals are to induce and maintain remission (symptomatic and endoscopic healing).
  • Current treatments include 5-aminosalicylic acid, steroids, and immunosuppressants.

Conclusions:

  • Ulcerative colitis management focuses on achieving and sustaining remission.
  • Colectomy may be necessary for refractory disease or neoplasia.
  • The range of treatments for ulcerative colitis is rapidly growing with new drug targets.