Related Experiment Video

Updated: Mar 10, 2026

Histological Quantification to Determine Lung Fungal Burden in Experimental Aspergillosis
09:52

Histological Quantification to Determine Lung Fungal Burden in Experimental Aspergillosis

Published on: March 9, 2018

11.1K

A CONSORT analysis of randomised controlled trials for the treatment of invasive aspergillosis

Brian L Jones1, Malcolm D Richardson2, Patricia M Ingram3

  • 1Department of Clinical Microbiology, Royal Infirmary, Glasgow, United Kingdom, and University of Glasgow, Glasgow, United Kingdom.

Medical Mycology
|December 5, 2016
PubMed

Insights

Reporting quality of antifungal randomized controlled trials (RCTs) for invasive aspergillosis (IA) is inconsistent. One trial report demonstrated significantly higher quality, impacting clinical recommendations.

Area of Science:

  • Medical Mycology
  • Clinical Trials Methodology
  • Evidence-Based Medicine

Background:

  • Guidelines for invasive aspergillosis (IA) treatment rely on antifungal randomized controlled trials (RCTs).
  • The reporting quality of these crucial RCTs has not been previously assessed.
  • Inconsistent reporting quality may affect the reliability of current treatment guidelines.

Purpose of the Study:

  • To evaluate the reporting quality of antifungal RCTs used in invasive aspergillosis (IA) treatment guidelines.
  • To identify variations in reporting standards among published trials.
  • To assess the potential impact of reporting quality on clinical recommendations.

Main Methods:

  • Searched Trip, Cochrane, Medline, and Embase for relevant antifungal RCTs.
  • Assessed trial report quality using the 25-item CONSORT checklist and a 4-point rating scale.
  • Calculated mean group-scores to quantify overall and specific domain reporting quality.

Main Results:

  • Seven antifungal RCTs met the inclusion criteria.
  • Overall mean reporting quality score was 2.44 out of 4, indicating moderate quality.
  • Significant variations in reporting quality were observed across trials (P < .001), particularly in Methods and Results sections.
  • The Cornely trial report exhibited the highest overall quality (3.15) and quality in Methods (3.36) and Results (3.40).

Conclusions:

  • The reporting quality of antifungal RCTs for IA varies significantly.
  • The superior reporting quality of the Cornely trial suggests it may provide more reliable data.
  • Incorporating CONSORT-based quality assessments into IA guideline development could refine clinical recommendations.
Keywords:
CONSORTRCThemato-oncologyinvasive aspergillosis

More Related Videos

Detection of Invasive Pulmonary Aspergillosis in Haematological Malignancy Patients by using Lateral-flow Technology08:01

Detection of Invasive Pulmonary Aspergillosis in Haematological Malignancy Patients by using Lateral-flow Technology

Published on: March 22, 2012

29.7K
Isolation of Culturable Yeasts and Molds from Soils to Investigate Fungal Population Structure10:33

Isolation of Culturable Yeasts and Molds from Soils to Investigate Fungal Population Structure

Published on: May 27, 2022

7.2K

Related Concept Videos

Randomized Experiments01:13

Randomized Experiments

The randomization process involves assigning study participants randomly to experimental or control groups based on their probability of being equally assigned. Randomization is meant to eliminate selection bias and balance known and unknown confounding factors so that the control group is similar to the treatment group as much as possible. A computer program and a random number generator can be used to assign participants to groups in a way that minimizes bias.
Simple randomization
Simple...
9.2K
Fungal Phylum Ascomycota01:28

Fungal Phylum Ascomycota

Phylum Ascomycota, a major division within the subkingdom Dikarya, comprises a diverse range of fungal species, including both unicellular yeasts and filamentous molds such as Aspergillus and Penicillium. These fungi thrive in a variety of habitats, from aquatic ecosystems to terrestrial environments, playing crucial ecological and economic roles.Morphology and ReproductionThe defining characteristic of Ascomycetes, commonly referred to as sac fungi, is the ascus—a sac-like structure that...
2.0K
Bioequivalence Experimental Study Designs: Completely Randomized and Randomized Block Designs01:20

Bioequivalence Experimental Study Designs: Completely Randomized and Randomized Block Designs

Bioequivalence experimental study designs are crucial methodologies used in evaluating and comparing the bioavailability of different drug products. These designs are categorized into various types: completely randomized, randomized block, repeated measures, cross and carry-over, and Latin square designs.Completely randomized designs involve randomly allocating treatments to all subjects participating in the experiment. This allocation is achieved by assigning unique random numbers to subjects...
348