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Genetic and Epigenetic Alterations in Bladder Cancer
Hong-Tao Li1, Christopher E Duymich1, Daniel J Weisenberger1,2
1Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
International Neurourology Journal
|December 6, 2016
Summary
Bladder cancer has frequent recurrences and high costs. This review explores genomic and epigenomic alterations in bladder cancer, identifying potential diagnostic markers and therapeutic targets.
Area of Science:
- Oncology
- Genetics
- Epigenetics
Background:
- Bladder cancer is a prevalent malignancy globally, characterized by high recurrence rates and significant treatment costs.
- Lifelong monitoring and treatment underscore the economic burden and clinical challenge of bladder cancer management.
- Distinct genetic and epigenetic alterations are increasingly recognized across different bladder cancer stages and grades.
Approach:
- This review synthesizes current evidence on genomic and epigenomic alterations in bladder cancer.
- Focuses on alterations implicated in bladder tumorigenesis.
- Highlights potential applications in diagnostics and therapeutics.
Key Points:
- Genomic alterations are crucial in bladder cancer development.
- Epigenomic changes also play a significant role in bladder tumorigenesis.
- Specific alterations offer potential as diagnostic markers and therapeutic targets.
Conclusions:
- Understanding bladder cancer's genomic and epigenomic landscape is vital.
- These alterations are key to developing improved diagnostic tools and targeted therapies.
- Further research into these molecular changes promises to enhance patient outcomes.
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